• We report a rare case of

  2018-11-12

  

  We report a rare case of complex distal fusiform RAA at the bifurcation of the left renal artery, for which endovascular intervention was not viable. Using hand-assisted laparoscopic nephrectomy combined with backbench repair and autotransplantation (which is a feasible, safe, and tolerable procedur

• br Clinical implication of liver

  2018-11-12

  

  Clinical implication of liver cancer stem cells in hepatocellular carcinoma HCC could be derived from either the putative periportal stem cells or from the transition duct cells or their progeny (hepatic genitor cells or oval cells). Recent reports have shown that CD133+ cells have stem cell char

• br Case Report Physical examination revealed normal response

  2018-11-12

  

  Case Report Physical examination revealed normal response in the patient\'s upper limbs and normal vital signs. Blood test results indicated no abnormalities; however, spinal MRI revealed an epidural mass lesion (10 mm × 12 mm × 63 mm) in the posterior epidural space from T9 to T11 in the spinal

• br Discussion Benign FH is usually

  2018-11-12

  

  Discussion Benign FH is usually of two types: cutaneous type and that involving deep soft tissues. Histologically, deep FH has many features in common with cutaneous cellular FH, including a storiform and/or short fascicular growth pattern, similar cytologic features with frequently limited or ab

• br Conclusion br Introduction Free

  2018-11-12

  

  Conclusion Introduction Free fibular osteocutaneous flaps are used worldwide for mandibular defect reconstruction after tumor ablation of head and neck cancer. Although these flaps have generally been accepted as suitable sources of vascularized bone grafts, donor-site morbidity remains a conc

• Previously we reported a chemical genetic screen that reveal

  2018-11-12

  

  Previously, we reported a chemical genetic screen that revealed that several statins activate a β-catenin-responsive luciferase reporter (BAR) in a cell-based assay (Biechele et al., 2010). This result supports prior in vitro studies that have shown that statins modulate Wnt/β-catenin signaling (hen

• Because cathepsins are located within lysosomes

  2018-11-12

  

  Because cathepsins are located within lysosomes and can be targeted by BA1, and because they participate in many cell death pathways, they are attractive candidates as effectors of charontosis in mESCs (Broker et al., 2004; Droga-Mazovec et al., 2008; Hsu et al., 2009; Kagedal et al., 2001; Zuzarte-

• br Discussion Generating neural stem cells from

  2018-11-12

  

  Discussion Generating neural stem ASA 404 from hESCs and iPSCs has been successfully achieved by a number of groups (Elkabetz et al., 2008; Falk et al., 2012; Koch et al., 2009; Nemati et al., 2011). However, the simplicity and retained – or even enhanced – differentiation versatility combined w

• Replicative senescence is another condition that can be

  2018-11-12

  

  Replicative senescence is another condition that can be preceded and propagated by a very similar cascade of proinflammatory signals, which is called a senescence-associated proinflammatory phenotype (SASP) (Velarde et al., 2013). Since this SASP can “infect” neighboring FLAG tag a condition can be

• Our results are in line with previous findings showing that

  2018-11-12

  

  Our results are in line with previous findings showing that cellular senescence negatively correlates with reprogramming efficiency (Banito et al., 2009; Mali et al., 2008; Qin et al., 2007; Zhao and Daley, 2008; Zhao et al., 2008). The expression of p21 is controlled by p53 during the replicative s

• br Resource details To generate the

  2018-11-12

  

  Resource details To generate the human iPSC line, N44SV.5, non-integrative Sendai viruses containing the reprogramming factors Oct3/4, Sox2, cMyc, Klf4 have been employed (Takahashi et al., 2007). For this purpose, commercially available fibroblasts from a healthy juvenile donor were acquired in

• Here we report that transient expression of NKX functions as

  2018-11-09

  

  Here, we report that transient expression of NKX2-1 functions as an inductive signal during thyroid-directed differentiation to convert AFE-stage igf 1 inhibitor to thyrocyte-like cells that self-organize to epithelial, follicle-like structures in 3D Matrigel culture. This thyroid conversion effect

• What is more intriguing is that

  2018-11-09

  

  What is more intriguing is that non-MNs undergo degeneration earlier than MNs. This is demonstrated by the fact that loss of non-MNs is already obvious in the spinal cord segment that is distant from the injection site and has partial (ventral gray matter) integration by human astrocytes. Unlike the

• Remarkably the process of dedifferentiation or reprogramming

  2018-11-09

  

  Remarkably, the process of dedifferentiation or reprogramming of somatic Chloroquine by Yamanaka factors (OCT3/4, SOX2, KLF4, and C-MYC), many of which are oncogenes, offers a new insight into CSCs (Schwitalla et al., 2013; Takahashi and Yamanaka, 2006). Almost any differentiated cell can be sent b

• The thermal field emission flux becomes substantial as

  2018-11-09

  

  The thermal field emission flux becomes substantial as the surface temperature reaches a certain value, namely The calculations show that the surface roughness reduces the effect of pkg inhibitor emission, and in fact at a sufficiently high degree of roughness (∼0.8) emission can be neglected (

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