• With limited natural resources such as land

  2018-11-08

  

  With limited natural resources such as land, water and energy, food security is not limited to developing countries but a global issue. The Food and Agriculture Organization of the United Nations (FAO) issued a report in 2011, estimated that almost one-third of food produced for human consumption (a

• Osteogenic differentiation as observed during intramembranou

  2018-11-08

  

  Osteogenic differentiation, as observed during intramembranous ossification, involves the following processes: (1) cell proliferation (2) cell migration–aggregation and (3) cell differentiation with the dynamic expression of osteogenic transcription and growth factors (Karner et al., 2009). To repli

• With the advent of factor based reprogramming induced

  2018-11-08

  

  With the advent of factor-based reprogramming, induced pluripotent stem cells can be readily obtained from patients with a variety of genetic diseases (Dimos et al., 2008; Park et al., 2008; Takahashi and Yamanaka, 2006), but several limitations exist to factor based reprogramming as models for dise

• The ability to generate human vascular endothelium

  2018-11-08

  

  The ability to generate human vascular endothelium from iPSCs is an enabling platform. Cell-based assays of endothelial function can be combined with ECs derived from iPSC lines produced from patients with genetic diseases, creating powerful model systems of human disease or associations where the p

• Comparative gene expression analysis of ex

  2018-11-08

  

  Comparative gene expression analysis of ex vivo expanded lung stromal ML365 also showed that the activation of an epithelial-supportive phenotype was associated with the reactivation of genes related to lung development, epithelial morphogenesis and angiogenesis. This suggests that the signaling p

• Unlike the paradigm of hypoxia at O

  2018-11-08

  

  Unlike the paradigm of “hypoxia” at 2% O2 emphasized by studies like those of the Fisher lab, we emphasize that “hypoxic” stress for stem metforman occurs at lower levels of O2 at ~0.5% which induce differentiation in the first 2days that favors the first lineage, but fails to support differentiati

• Despite the high degree of

  2018-11-08

  

  Despite the high degree of similarity between SCDSs and the lack of strict segregation by function, we did identify genes that were highly over-represented by comparing 3 M-SCDSs and 3 F-SCDSs (see Supplementary Information for the role of these differentially expressed genes in skeletogenesis, oste

• br Source of funding This work

  2018-11-08

  

  Source of funding This work was supported by research funding from The Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research (C) (22591555) and the Riken Center for Developmental Biology Collaborative Research Fund, Kobe (08001475). Disclosures

• br Introduction Developmental myelination and

  2018-11-08

  

  Introduction Developmental myelination and myelin repair after demyelination are mediated by oligodendrocyte precursor cells (OPCs). OPCs are characterized by markers such as PDGFRα and the chondroitin sulfate proteoglycan NG2 (Dubois-Dalcq et al., 2008; Franklin and Ffrench-Constant, 2008; Nishi

• It has long been known that

  2018-11-08

  

  It has long been known that mesenchymal stem EZ Cap Reagent AG (MSCs) are capable of differentiation along the mesenchymal lineages, forming adipose tissue (adipocytes), cartilage (chondrocytes) and bone (osteoblasts) (Pittenger et al., 1999, 2000). MSCs can be isolated from a number of tissues, inc

• Transplantation of c kit RCSC

  2018-11-08

  

  Transplantation of c-kit+ RCSC shifted the balance between pro- and anti-angiogenic proteins in the pressure-overloaded LV myocardium towards pro-angiogenic mediators and the myocardium of transplanted mice showed an increased density of endothelial (CD31+) cells. In contrast, GFP+ cardiomyocytes we

• While i n administered MSCs were clearly detected

  2018-11-08

  

  While i.n-administered MSCs were clearly detected in the lungs of normal mice, and to a greater extent, the inflamed lungs of mice with chronic AAD 48h later, previous studies in murine models of kidney disease (Huuskes et al., 2015; Togel et al., 2008) had shown that these ppar antagonist could no

• While i n administered MSCs were clearly detected

  2018-11-08

  

  While i.n-administered MSCs were clearly detected in the lungs of normal mice, and to a greater extent, the inflamed lungs of mice with chronic AAD 48h later, previous studies in murine models of kidney disease (Huuskes et al., 2015; Togel et al., 2008) had shown that these order dihydroergotamine m

• The following is the supplementary data

  2018-11-08

  

  The following is the supplementary data related to this article. Authors\' contributions O.F. contributed to prepare experimental design, performed Ca measurements, helped with data and statistical analysis, immunocytochemistry, confocal imaging, and contributed in manuscript writing. Disclos

• itk inhibitor In conclusion an MLR assay

  2018-11-08

  

  In conclusion, an MLR assay using hiPSC-NS/PCs revealed no significant differences between the HLA-matched and mismatched settings. The low antigen-presenting function and immunosuppressive effects of hiPSC-NS/PCs resulted in decreased immune reactions, even in the allogeneic HLA-mismatched NS/PC-PB

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