Our findings showing an increase of growth factors expressio

2018-10-20

Our findings showing an increase of growth factors expression in miR133-CPCs upon stress conditioning and the amelioration of cardiac functions after miR133-CPCs transplantation post-AMI are in agreement with a recent publication that demonstrates that previous supplementation (“priming”) of SCA1+/C

Pathway analysis on these genes identified their role

2018-10-20

Pathway analysis on these genes identified their role in stem-cell-maintenance-related Wnt pathway (Baker, 2010), cell-cycle-related p53 pathway, JAK stat, and MAPK pathways in addition to others listed in Table S4. These results suggest a potential contribution of multiple signaling pathways for st

Main Text In little more than a decade stem cell

2018-10-20

Main Text In little more than a decade, stem cell science has moved rapidly from discovery to testing in the clinic. Hundreds of stem cell clinical trials are estimated to be underway for a wide range of conditions (Trounson et al., 2011, 2012). A 2013 Pharmaceutical Research and Manufacturers of A

br Experimental Procedures br Author

2018-10-20

Experimental Procedures Author Contributions Acknowledgments We thank Keisuke Okita and Shinya Yamanaka for providing the hiPSC lines 409B2 and 604B1, Knut Woltjen for providing PB-MCSII, Akitsu Hotta for providing the PBase II vector and instructions for transducing the piggyBac vectors, a

Plasmid electroporation EP to the brain has become a commonl

2018-10-20

Plasmid electroporation (EP) to the formyl has become a commonly used method of in vivo transgenesis in development (Breunig et al., 2007; Saito and Nakatsuji, 2001). However, like most episomal methods of transgenesis, EP suffers from plasmid dilution (Chen and LoTurco, 2012). Thus, studying compl

Our study shows that iPSCs are highly proficient in antioxid

2018-10-20

Our study shows that iPSCs are highly proficient in antioxidant defense, which is presumably responsible for the low frequency of oxidative DNA lesions in both the mitochondrial and nuclear genome. Notably, previous non-quantitative proteomic studies revealed an abundant expression of antioxidant en

AZD1208 The Xenopus homolog of Bucky ball is

2018-10-20

The Xenopus homolog of Bucky ball is known as XVelo (Vegetally localized −1), first identified based on the vegetal pole localization of XVelo RNA (Claussen and Pieler, 2004). A recent study identified XVelo as a Balbiani body enriched protein, and identified prion-like sequences within the amino te

Importantly expression of SMA is not simply

2018-10-20

Importantly, expression of α-SMA is not simply a marker for MF activation, but also the driver of cell function and fate. Increased expression of α-SMA directly reduces the clonal potential of hMSCs and guides their differentiation toward osteoblasts. Hence, α-SMA not only identifies osteoprogenitor

Although diversification of the secondary prosencephalon int

2018-10-20

Although diversification of the secondary prosencephalon into telencephalon, eye field, and hypothalamus has been difficult to dissect in vivo, it can be modeled in vitro using mouse and human embryonic stem FG-4592 (mESCs and hESCs, respectively). In these culture systems, both endogenous and exog

During differentiation mitochondrial maturation requires a

2018-10-20

During differentiation, mitochondrial maturation requires a dynamic network and a continuous balance between fission and fusion processes. The balance is maintained via quality control of mitochondrial fission and fusion proteins. Drp1 (Yoon et al., 2003), a key mitochondria protein controlling fiss

Hello world!

2018-07-29