Our study shows that iPSCs are highly proficient in antioxid

2018-10-20

Our study shows that iPSCs are highly proficient in antioxidant defense, which is presumably responsible for the low frequency of oxidative DNA lesions in both the mitochondrial and nuclear genome. Notably, previous non-quantitative proteomic studies revealed an abundant expression of antioxidant en

AZD1208 The Xenopus homolog of Bucky ball is

2018-10-20

The Xenopus homolog of Bucky ball is known as XVelo (Vegetally localized −1), first identified based on the vegetal pole localization of XVelo RNA (Claussen and Pieler, 2004). A recent study identified XVelo as a Balbiani body enriched protein, and identified prion-like sequences within the amino te

Importantly expression of SMA is not simply

2018-10-20

Importantly, expression of α-SMA is not simply a marker for MF activation, but also the driver of cell function and fate. Increased expression of α-SMA directly reduces the clonal potential of hMSCs and guides their differentiation toward osteoblasts. Hence, α-SMA not only identifies osteoprogenitor

Although diversification of the secondary prosencephalon int

2018-10-20

Although diversification of the secondary prosencephalon into telencephalon, eye field, and hypothalamus has been difficult to dissect in vivo, it can be modeled in vitro using mouse and human embryonic stem FG-4592 (mESCs and hESCs, respectively). In these culture systems, both endogenous and exog

During differentiation mitochondrial maturation requires a

2018-10-20

During differentiation, mitochondrial maturation requires a dynamic network and a continuous balance between fission and fusion processes. The balance is maintained via quality control of mitochondrial fission and fusion proteins. Drp1 (Yoon et al., 2003), a key mitochondria protein controlling fiss

Hello world!

2018-07-29