• Sca mice demonstrate deficiency in

  2018-10-20

  

  Sca-1−/− mice demonstrate deficiency in MMP activity and enhanced fibrosis in muscle (Kafadar et al., 2009). In addition, these mice develop insulin resistance and glucose intolerance when exposed to a HFD (Staszkiewicz et al., 2012). Recent studies suggest that Sca-1+ pkc inhibitors in the adipose

• AEG 3482 Furthermore we have identified the

  2018-10-20

  

  Furthermore, we have identified the tumour stroma, and pancreatic stellate AEG 3482 in particular, to be an abundant source of NODAL and ACTIVIN, thus creating a supportive niche for these highly plastic cells (Lonardo et al., 2012). Since pancreatic cancers are usually highly desmoplastic tumours

• In summary using the Nurr agonist AQ we first showed

  2018-10-20

  

  In summary, using the Nurr1 agonist AQ we first showed that Nurr1 plays an important role in the regulation of adult hippocampal neurogenesis. AQ may increase adult hippocampal neurogenesis via, in part, an up-regulated phosphorylation of Akt and ERK1/2. Moreover, the Nurr1 agonist enhances both sho

• Chromatin at mammalian telomeres is underacetylated and shar

  2018-10-20

  

  Chromatin at mammalian telomeres is underacetylated and shares the typical features of other repeat-containing constitutive heterochromatic elements, such as pericentric chromatin. Telomeric repeats are also enriched for H3K9me3, which represents a docking site for the binding of HP1 isoforms (Benet

• We used immunohistochemistry to measure the expression

  2018-10-20

  

  We used immunohistochemistry to measure the expression of RUNX2, SP7, and GFP in the induced 2.3 kb Col1a1-GFP mESCs. RUNX2, SP7, and the 2.3 kb Col1a1-GFP were highly expressed in the induced Asiaticoside on day 19. RUNX2 and SP7 were colocalized in nuclei, and 2.3 kb Col1a1-GFP was largely observ

• We used immunohistochemistry to measure the expression

  2018-10-20

  

  We used immunohistochemistry to measure the expression of RUNX2, SP7, and GFP in the induced 2.3 kb Col1a1-GFP mESCs. RUNX2, SP7, and the 2.3 kb Col1a1-GFP were highly expressed in the induced iib iiia inhibitors on day 19. RUNX2 and SP7 were colocalized in nuclei, and 2.3 kb Col1a1-GFP was largely

• In this regard induced pluripotent stem cells iPSCs converge

  2018-10-20

  

  In this regard, induced pluripotent stem fatty acid amide hydrolase (iPSCs) converge to a better-defined ground state of pluripotency (Hackett et al., 2013). They can be differentiated into all cell types of the organism and—while in pluripotent state—cultured virtually indefinitely without signs o

• Our findings showing an increase of growth factors expressio

  2018-10-20

  

  Our findings showing an increase of growth factors expression in miR133-CPCs upon stress conditioning and the amelioration of cardiac functions after miR133-CPCs transplantation post-AMI are in agreement with a recent publication that demonstrates that previous supplementation (“priming”) of SCA1+/C

• Pathway analysis on these genes identified their role

  2018-10-20

  

  Pathway analysis on these genes identified their role in stem-cell-maintenance-related Wnt pathway (Baker, 2010), cell-cycle-related p53 pathway, JAK stat, and MAPK pathways in addition to others listed in Table S4. These results suggest a potential contribution of multiple signaling pathways for st

• Main Text In little more than a decade stem cell

  2018-10-20

  

  Main Text In little more than a decade, stem cell science has moved rapidly from discovery to testing in the clinic. Hundreds of stem cell clinical trials are estimated to be underway for a wide range of conditions (Trounson et al., 2011, 2012). A 2013 Pharmaceutical Research and Manufacturers of A

• br Experimental Procedures br Author

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments We thank Keisuke Okita and Shinya Yamanaka for providing the hiPSC lines 409B2 and 604B1, Knut Woltjen for providing PB-MCSII, Akitsu Hotta for providing the PBase II vector and instructions for transducing the piggyBac vectors, a

• Plasmid electroporation EP to the brain has become a commonl

  2018-10-20

  

  Plasmid electroporation (EP) to the formyl has become a commonly used method of in vivo transgenesis in development (Breunig et al., 2007; Saito and Nakatsuji, 2001). However, like most episomal methods of transgenesis, EP suffers from plasmid dilution (Chen and LoTurco, 2012). Thus, studying compl

• Our study shows that iPSCs are highly proficient in antioxid

  2018-10-20

  

  Our study shows that iPSCs are highly proficient in antioxidant defense, which is presumably responsible for the low frequency of oxidative DNA lesions in both the mitochondrial and nuclear genome. Notably, previous non-quantitative proteomic studies revealed an abundant expression of antioxidant en

• AZD1208 The Xenopus homolog of Bucky ball is

  2018-10-20

  

  The Xenopus homolog of Bucky ball is known as XVelo (Vegetally localized −1), first identified based on the vegetal pole localization of XVelo RNA (Claussen and Pieler, 2004). A recent study identified XVelo as a Balbiani body enriched protein, and identified prion-like sequences within the amino te

• Importantly expression of SMA is not simply

  2018-10-20

  

  Importantly, expression of α-SMA is not simply a marker for MF activation, but also the driver of cell function and fate. Increased expression of α-SMA directly reduces the clonal potential of hMSCs and guides their differentiation toward osteoblasts. Hence, α-SMA not only identifies osteoprogenitor

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