• Previously we reported a chemical genetic screen that reveal

  2018-11-12

  

  Previously, we reported a chemical genetic screen that revealed that several statins activate a β-catenin-responsive luciferase reporter (BAR) in a cell-based assay (Biechele et al., 2010). This result supports prior in vitro studies that have shown that statins modulate Wnt/β-catenin signaling (hen

• Because cathepsins are located within lysosomes

  2018-11-12

  

  Because cathepsins are located within lysosomes and can be targeted by BA1, and because they participate in many cell death pathways, they are attractive candidates as effectors of charontosis in mESCs (Broker et al., 2004; Droga-Mazovec et al., 2008; Hsu et al., 2009; Kagedal et al., 2001; Zuzarte-

• br Discussion Generating neural stem cells from

  2018-11-12

  

  Discussion Generating neural stem ASA 404 from hESCs and iPSCs has been successfully achieved by a number of groups (Elkabetz et al., 2008; Falk et al., 2012; Koch et al., 2009; Nemati et al., 2011). However, the simplicity and retained – or even enhanced – differentiation versatility combined w

• Replicative senescence is another condition that can be

  2018-11-12

  

  Replicative senescence is another condition that can be preceded and propagated by a very similar cascade of proinflammatory signals, which is called a senescence-associated proinflammatory phenotype (SASP) (Velarde et al., 2013). Since this SASP can “infect” neighboring FLAG tag a condition can be

• Our results are in line with previous findings showing that

  2018-11-12

  

  Our results are in line with previous findings showing that cellular senescence negatively correlates with reprogramming efficiency (Banito et al., 2009; Mali et al., 2008; Qin et al., 2007; Zhao and Daley, 2008; Zhao et al., 2008). The expression of p21 is controlled by p53 during the replicative s

• br Resource details To generate the

  2018-11-12

  

  Resource details To generate the human iPSC line, N44SV.5, non-integrative Sendai viruses containing the reprogramming factors Oct3/4, Sox2, cMyc, Klf4 have been employed (Takahashi et al., 2007). For this purpose, commercially available fibroblasts from a healthy juvenile donor were acquired in

• Here we report that transient expression of NKX functions as

  2018-11-09

  

  Here, we report that transient expression of NKX2-1 functions as an inductive signal during thyroid-directed differentiation to convert AFE-stage igf 1 inhibitor to thyrocyte-like cells that self-organize to epithelial, follicle-like structures in 3D Matrigel culture. This thyroid conversion effect

• What is more intriguing is that

  2018-11-09

  

  What is more intriguing is that non-MNs undergo degeneration earlier than MNs. This is demonstrated by the fact that loss of non-MNs is already obvious in the spinal cord segment that is distant from the injection site and has partial (ventral gray matter) integration by human astrocytes. Unlike the

• Remarkably the process of dedifferentiation or reprogramming

  2018-11-09

  

  Remarkably, the process of dedifferentiation or reprogramming of somatic Chloroquine by Yamanaka factors (OCT3/4, SOX2, KLF4, and C-MYC), many of which are oncogenes, offers a new insight into CSCs (Schwitalla et al., 2013; Takahashi and Yamanaka, 2006). Almost any differentiated cell can be sent b

• The thermal field emission flux becomes substantial as

  2018-11-09

  

  The thermal field emission flux becomes substantial as the surface temperature reaches a certain value, namely The calculations show that the surface roughness reduces the effect of pkg inhibitor emission, and in fact at a sufficiently high degree of roughness (∼0.8) emission can be neglected (

• Fig displays associations between number

  2018-11-09

  

  Fig. 4 displays associations between number of children and parental weight from our a priori specified stratified analyses. Each graph presents the adjusted estimates from a stratified regression model; the sample size and P-values associated with the child count and the child-count/gender interact

• Research quantifying community capacity has identified stati

  2018-11-09

  

  Research quantifying g protein coupled receptors capacity has identified statistically significant differences amongst neighbourhoods (Jung & Rhee, 2013) and between towns (Lovell et al., 2015a), thus confirming the importance of place to our social relationships. Place is recognised by geographers

• br Data and methods To assess these possibilities we

  2018-11-09

  

  Data and methods To assess these possibilities we analyze data from the China Family Panel Studies (CFPS), and include information from interviews conducted in 2010 (Wave 1) and 2012 (Wave 2). The CFPS uses a nationally representative multi-stage probability sample, with counties (or equivalent)

• In early a serious ZIKV outbreak was recorded in Cama

  2018-11-09

  

  In early 2015, a serious ZIKV outbreak was recorded in Camaçari, Bahia, Brazil (Plourde and Bloch, 2016; Cerbino-Neto et al., 2016) and this was later followed by similar illnesses in five neighboring states leading the Ministry of Health to issue a ZIKV alert in April (Rasmussen et al., 2016; Chan

• The androgen receptor AR is

  2018-11-09

  

  The androgen receptor (AR) is a ligand-dependent transcriptional factor that belongs to the nuclear receptor superfamily. Androgen/AR signals play important roles in normal liver function and in the development of liver diseases including HCC (Ma et al., 2014). Previous studies revealed a male predo

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