• In addition to Rabs several proteins have been shown

  2022-05-17

  

  In addition to Rabs, several proteins have been shown to interact with Rabphilin3a, for instance the GluN2A subunit of the NMDA receptor, PSD-95 ([56,57] and references therein), Rabaptin-5, α-actinin [16] and SNAP-25 [21,23,41,61]. Only the latter has been reported to participate in the AR. Explori

• Recently results obtained by our group have demonstrated tha

  2022-05-17

  

  Recently, results obtained by our group have demonstrated that hEECs are able to secrete NPY into the extracellular medium and that this peptide can induce an increase in the [Ca]i of these cells (Jacques et al., 2003b). In light of these results and those obtained in this study, we can speculate th

• Compounds and were evaluated for their pharmacokinetic

  2022-05-17

  

  Compounds and were evaluated for their pharmacokinetic properties in rats and the results are summarized in . Following intravenous (IV) administration, both compounds displayed low clearance (CL), short half-lives (t) and low volumes of distribution (V). When dosed orally as a solution, exposure

• br STAR Methods br Acknowledgments Funding for this work

  2022-05-17

  

  STAR★Methods Acknowledgments Funding for this work was provided by grants from the US National Institute of Allergy and Infectious Diseases (NIAID) (R01-AI095068 and UM1-AI068613 to S.H.E. and U24-AI118633 to H.B.L.) and grant OPP1155863 from the Bill and Melinda Gates Foundation to S.J.E. Add

• br Significance Cellular heterogeneity for phenotypic featur

  2022-05-17

  

  Significance Cellular heterogeneity for phenotypic features is a key mechanism underlying disease progression and therapeutic resistance, yet its regulation is poorly understood at the molecular level. Our findings demonstrate that endocrine resistance is associated with higher transcriptomic het

• br Conclusion Our data allow pharmacological

  2022-05-17

  

  Conclusion Our data allow pharmacological discrimination of diverse of H3 histone methyltransferase antagonists that can be linked to their differential efficacy in preclinical and clinical disease settings (Fig. 6). Moreover, we identify the sigma-1 receptor as a common “off target” for H3 anta

• br Conclusion br Acknowledgement br

  2022-05-17

  

  Conclusion Acknowledgement Introduction Biogenic amine histamine is synthesized from L-histidine by histidine decarboxylase (HDC). Histamine is involved in a wide variety of pathological and physiological processes including allergic reactions, inflammation, immune responses, gastric secret

• Desfuroylceftiofur australia Importantly recent in vivo resu

  2022-05-17

  

  Importantly, recent in vivo results demonstrated that combining an HDACi and a IKK inhibitor significantly reduced ovarian tumor growth compared with either inhibitor alone [26]. The slowest tumor growth in the HDACi/IKK inhibition combination group was associated with the lowest CXCL8 tumor and pla

• br Conclusion br Funding br Availability of data and

  2022-05-17

  

  Conclusion Funding Availability of data and materials Authors' contributions Ethics approval and consent to participate Consent for publication Competing interests Introduction Hepatitis C virus (HCV) infection is a global public health problem. An estimated 71.1 million peop

• br Materials and methods br Results br Discussion I have

  2022-05-17

  

  Materials and methods Results Discussion I have identified an alternative transcript of the integrin αE gene that is abundantly expressed in testis. In humans, this transcript (hAED) includes part of intron 26 and exons 27, 29, 30, and 31 of the conventional αE gene and Northern analysis in

• methysergide synthesis NCSs are helical proteins containing

  2022-05-17

  

  NCSs are α-helical proteins containing four EF-hand motifs with EF1 being incapable of Ca-binding throughout the family (atomic-resolution structure was firstly resolved for recoverin [5]; for review on NCS structure, see [6]). Some of the NCS proteins (i.e. recoverin and KChIP3) have two while othe

• br Concluding remarks br Conflict of interest

  2022-05-17

  

  Concluding remarks Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements We thank all the present and former members in our laboratory for their contributions to

• br Ketone body metabolism and neuronal excitability One of t

  2022-05-17

  

  Ketone body metabolism and neuronal excitability One of the best examples of the close connection between metabolism and neuronal excitability is illustrated by the effect of ketone bodies on epileptic seizures. One third of patients suffering from epileptic seizures do not respond to convention

• While PLGA implants could be

  2022-05-17

  

  While PLGA implants could be beneficial for regenerative angiogenesis in the context of wound healing, they BMS 753 australia could also lead to adverse effects. Indeed, extracellular acidification inhibits osteoblast proliferation, differentiation, and extracellular matrix mineralization, which mig

• br Acknowledgments We thank Dr

  2022-05-17

  

  Acknowledgments We thank Dr Kathleen Sullivan of Merck Research Laboratories for providing the CHO-K1 l-name expressing an NFAT-β-lactamase reporter and the Gα subunit Gqi5, Dr. Chen Liaw (Arena Pharmaceutical), Ms. Rebecca Kaplan, Mr. Frank Xiaodong Gan for technical assistance, Dr. Andrew Howa

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