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br Materials and methods br Results br Discussion The major
2022-03-11
Materials and methods Results Discussion The major findings of the present study are that: 1) the response to inverse agonists may be crossregulated by the activation of either signal transducer and activator of transcription 6 fragment H1 or H2 receptors, 2) histamine H1 and H2 receptor i
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The GPR gene was included in our survey
2022-03-11
The GPR35 gene was included in our survey because of its location immediately 3′ to CAPN10 and because it showed evidence of association with type 2 diabetes. Also, its expression in tissues including pancreatic islets and skeletal muscle is consistent with a possible role in type 2 diabetes. Our re
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To apply the recently developed GPR ligands to
2022-03-11
To apply the recently developed GPR35 ligands to CNS disorders, it is necessary to understand whether GPR35 is expressed by any identified cell types in the melk pathway and whether activation or blockade of this receptor has any consequence on the activity of the neuronal circuitry. To this end, t
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br Conflict of interest br Acknowledgment This
2022-03-11
Conflict of interest Acknowledgment This work was supported by National Program on Key Basic Research Project of China (No. 2013CB127305); The National Natural Science Foundation of China (No. 314020785); Hubei Provincial Creative Team Project of Agricultural Science and Technology (No. 2007-6
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A number of synthetic GPR
2022-03-11
A number of synthetic GPR119 agonists have been reported to date, several of which have advanced into clinical trials. Reported GPR119 agonists are often composed of three parts as depicted in : a piperidine or a piperazine ring -substituted with a carbamate or a heteroaryl group at the right side,
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Milligan et al demonstrated the important role of
2022-03-11
Milligan et al. [31] demonstrated the important role of TNF-α, IL-6 and IL-1β in the development of mechanical hyperalgesia induced by intrathecal injection of gp120. Because of this work, we decide to produce and purify gp120 to develop biological systems to study pain and behavior in rodents. Intr
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The fact that KNDy neurons activity is sensitive
2022-03-11
The fact that KNDy neurons activity is sensitive for circulating hormones related with control of Rosiglitazone homeostasis was demonstrated in other studies (Cejudo Roman et al., 2012; Navarro et al., 2011). It is well documented that leptin plays an important role in the regulation of the gonadot
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By regulation of synaptic glutamate concentration glutamate
2022-03-11
By regulation of synaptic glutamate concentration, glutamate transporters play an important role in limiting glutamate signaling and controlling the activation of glutamate receptors (Rimmele and Rosenberg, 2016). Reduced glutamate transport is thought to underlie the pathogenesis of numerous neurol
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Acute effects of FZ were not altered in
2022-03-11
Acute effects of FZ were not altered in GluR-A−/− mice, thus providing a solid basis for comparing the effects of repeated drug administration. In addition, GluR-A subunit deficiency did not affect the basal behavior of saline-treated animals, despite the GluR-A−/− mice having been described as hype
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Regarding the causative diseases of ES patients
2022-03-11
Regarding the causative diseases of ES, patients with unknown cause and those with encephalitis had significantly higher CSF levels of GKT137831 against GluN2B-NT2 and GluN2B-CT than the disease controls, but patients with genetic disorder and those with cortical dysplasia showed no significant dif
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br Molecular aberrations in the FGFR
2022-03-10
Molecular aberrations in the FGFR signaling pathway Non–small cell lung cancer Small cell lung cancer Integrated IGF-1, human recombinant synthesis analysis revealed focal amplification of FGFR1 in 6% of SCLC cases. In another study with PD173074, Pardo et al. used two human SCLC xenograft
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Another TKI used in cancer therapy is the
2022-03-10
Another TKI used in cancer therapy is the Abl inhibitor imatinib mesilate which has also a beneficial effect on glucose homeostasis in diabetic humans [39], [40], [41]. Imatinib has a clear impact on NFκB activation and anti-apoptotic preconditioning of β-cells [39], attenuating islet inflammation [
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Contrary to the transient nature of signal transmission thro
2022-03-10
Contrary to the transient nature of signal transmission through PLCβ, genome-wide RNAi screens revealed that the signaling events driven by Gαq that result in aberrant cell proliferation depends on highly specific protein-protein interactions, rather than solely on diffusible second messenger system
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The current lack of effective treatments
2022-03-10
The current lack of effective treatments for primary or metastatic UM leaves a large therapeutic gap for patients and clinicians underscoring an urgent need for the identification of additional pharmacological targets for therapeutic intervention. As YAP-targeting strategies have remained elusive th
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Recently results obtained by our group
2022-03-10
Recently, results obtained by our group have demonstrated that hEECs are able to secrete NPY into the extracellular medium and that this peptide can induce an increase in the [Ca]i of these cells (Jacques et al., 2003b). In light of these results and those obtained in this study, we can speculate th
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