• br Materials and methods br Results br Discussion Numerous s

  2021-12-29

  

  Materials and methods Results Discussion Numerous studies have identified important roles for HIF-1α in cellular function and dysfunction through its transcriptional activity [4]. A few studies have reported that HIF-1α is translocated to the mitochondria in human and mouse cancer cell line

• Wolf et al then proceed to interrogate the

  2021-12-29

  

  Wolf et al. (2016) then proceed to interrogate the mechanism by which NAG activates the NLRP3 inflammasome. When examining potential triggers previously implicated in NLRP3 activation, they found that both PGN and NAG trigger appearance of mitochondrial DNA (mtDNA) in the cytosol, which led them to

• br Acknowledgments This review is based in part on

  2021-12-29

  

  Acknowledgments This review is based in part on research conducted with financial support from the General Research Fund (17112914) of the Hong Kong Research Grant Council and from the Seed Funding Programme for Basic Research by University Research Committee of the University of Hong Kong (20151

• In the Toc Regulator Mode Fig recognition of

  2021-12-29

  

  In the “Toc34 Regulator Mode” (Fig. 6), recognition of the transit peptide by Toc159 monomer (step 4) leads to heterodimer-formation [18]. Subsequently, preprotein interaction with the Toc34G homodimer (step 1) regulates the Toc34G homodimer (step 2, 3). However, this mode requires a parallel induct

• br Glycoengineering br The Omics perspective The

  2021-12-29

  

  Glycoengineering The « Omics » perspective The publication of the CHO-K1 genome sequence in 2011, followed by the publication of two Chinese hamster and six CHO cell line genomes in 2013, bring new opportunities in developing and engineering CHO Oxybutynin for improved glycoprotein production

• Bergmann glia cells BGCs are

  2021-12-29

  

  Bergmann glia Direct Mouse Genotyping Kit synthesis (BGCs) are the most abundant glia cells in the cerebellum, comprising more than 90% of the cerebellar glia. These cells span the entire cerebellar molecular layer and encapsulate neuronal somata, dendrites and axons. BGC are involved in neurotrans

• br Conclusion Until recently astrocytes

  2021-12-29

  

  Conclusion Until recently, astrocytes were recognized solely for their maintenance role in the regulation of annexin v homeostasis. Nowadays, this idea has changed, it is clear that these cells play a crucial role in the regulation of neuronal activity and signal transmission. In particular, glia

• br Author contribution br Declaration of interest br

  2021-12-29

  

  Author contribution Declaration of interest Acknowledgements This work was supported by National Natural Science Foundation of China (Grants 81473093) and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM1601ZZ-02). Introduction Diabetes represents a majo

• With the advent of genome

  2021-12-29

  

  With the advent of genome sequencing, hexokinase gene sequences are now available from a far greater number of vertebrate species, as well as from diverse non-vertebrate animal species. As indicated above, searches of vertebrate genome sequences revealed the existence of a novel fifth member of the

• The eradication of agonist activity in compound

  2021-12-28

  

  The eradication of agonist activity in compound was also confirmed in the ex vivo growth hormone (GH) release experiment conducted in isolated primary rat pituitary Alisol A synthesis as shown in . Compound did not produce any noticeable GH secretion at up to 10μM concentration. It could also ant

• Since our new compound Fex could be a new

  2021-12-28

  

  Since our new compound Fex-3 could be a new FXR ligand, we try to demonstrate that Fex-3 was an intestinal-restricted FXR agonist which only activated FXR in the intestine not in the liver or other organs. Initially, we investigated this in Caco-2 mg molecular weight with transwell experiments. Fro

• br Introduction Farnesoid X receptor FXR is

  2021-12-28

  

  Introduction Farnesoid X receptor (FXR) is a bile sodium channels regulated nuclear receptor highly expressed in the liver, intestine, kidney and adrenal glands in rodents.1, 2, 3, 4 FXR regulates transport proteins, the bile salt export pump (BSEP) and the organic solute transporter α (OSTα) th

• Arotinoid Acid Several observations about structure activity

  2021-12-28

  

  Several observations about structure–activity relationships can be made from this series, including that: (1) all lead compounds are NSAIDs of the 2-arylpropionic Arotinoid Acid class, (2) analogues with -oriented aryl substituents showed the best inhibition of FAAH, and (3) replacing the ether link

• AD is a major neurological disorder usually effecting the

  2021-12-28

  

  AD is a major neurological disorder, usually effecting the elderly population, which is difficult to diagnose until symptoms begin to accumulate. As of 2013, approximately five million Americans were living with AD. The number with this disease is projected to be 16 million by 2050 (Hebert et al., 2

• br Results br Discussion A key step in

  2021-12-28

  

  Results Discussion A key step in the regulation of gene etravirine is the methylation on H3K4, which is added by the multi-component MLL/COMPASS-like histone methyltransferases. Many studies have shown the requirement of shared core subunits for optimal methylation activity of catalytic SET pr

15488 records 485/1033 page Previous Next First page 上5页 481482483484485 下5页 Last page