• The elastase induced injury model has been shown to

  2020-03-09

  

  The elastase-induced injury model has been shown to produce airspace enlargement, and increases in lung volume and compliance that are similar to those observed in human patients (Hantos et al., 2008, Hamakawa et al., 2011). Thus, this model, which has been used to study emphysema, should be adequat

• Canine ANGPTL7 / Angiopoietin-like 7 Protein (Fc Tag) br Ac

  2020-03-07

  

  Acknowledgements Introduction Water and electrolytes constitute an integral part of all living things, and Canine ANGPTL7 / Angiopoietin-like 7 Protein (Fc Tag) governing their movements play important roles in a wide variety of physiological and/or pathophysiological processes. Given the imp

• Resistance to avermectins has been

  2020-03-07

  

  Resistance to avermectins has been associated with point mutations of GluCls in C. elegans, D. melanogaster, T. urticae and P. xylostella (Dent et al., 2000; Dermauw et al., 2012; Kane et al., 2000; Kwon et al., 2010; Wang et al., 2016a, 2017). Our electrophysiological study found a 8.2-fold reducti

• br Introduction Cell transplantation therapies using

  2020-03-07

  

  Introduction Cell transplantation therapies using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC)-derived retinal tissue (ESC/iPSC retina) or thyrotropin releasing hormone have emerged as therapeutic options for retinal degeneration following recent breakthroughs. A number of g

• pyk2 In a study performed simultaneously by another group

  2020-03-07

  

  In a study performed simultaneously by another group, EWS-FLI-1 introduction into unsorted murine bone marrow-derived pyk2 resulted in tumors with various phenotypes including one that is consistent with that of Ewing sarcoma [68]. The tumors expressed markers associated with Ewing sarcoma and disp

• Introduction Psoriasis is a chronic recurrent and inflammato

  2020-03-07

  

  Introduction Psoriasis is a chronic, recurrent and inflammatory skin disease, and it is characterized by erythema, skin hyperplasia, scales, and hyperproliferation of keratinocyte [1]. It is reported that the psoriasis occurrences are about 3% worldwide [2], but the number varies depending on ethni

• As a support chitosan presents

  2020-03-07

  

  As a support, chitosan presents interesting characteristics that reinforce its great potential for enzyme immobilization [18,19]. Firstly, it is produced from renewable natural sources in addition to being biodegradable and water insoluble [20,21]. Also, the main peculiarity in the chitosan structur

• Our results from neutropenic mice infected with both

  2020-03-07

  

  Our results from neutropenic mice infected with both fungal strains revealed that the inflammatory process was more severe 72hours post-infection (Fig. 4). Angioinvasion was mainly observed 48hours after infection for both strains. Transformation of A. fumigatus conidia into hyphae in immunocompeten

• One of the most fundamental distinctions

  2020-03-07

  

  One of the most fundamental distinctions between Ub signals is substrate monoubiquitination versus polyubiquitination. With the exception of the E2, UBE2W, which represents a special case because it SID 26681509 only ubiquitinates the flexible N-termini of substrates [5], [6], [20], most examples o

• Moreover maintaining the pyrimidine pool is

  2020-03-07

  

  Moreover, maintaining the pyrimidine pool is not the only important role played by DHODHs. In Toxoplasma gondii, for instance, DHODH plays a second essential function [38] possibly coupled to the mitochondrial respiratory activity, where it replenishes ubiquinol levels and prevents reactive oxygen s

• br Results This study was

  2020-03-07

  

  Results This study was carried out with a series of engineered extracellular matrix films of collagen assembled at hydrophobic surfaces, which allow for independent control of supramolecular structure, mechanical stiffness, and receptor recognition sites [17], [21]. Vascular smooth muscle BS-181

• The binding of collagen X to DDR differs from

  2020-03-07

  

  The binding of collagen X to DDR2 differs from the binding of collagen X to α2β1 integrin in that the triple helical conformation is essential for DDR2 binding. We previously reported that heat denatured pepsinised collagen X supported cell adhesion via α2β1, indicating that the triple-helical confo

• In order to gain further insights into the

  2020-03-07

  

  In order to gain further insights into the role of peptidases in B. xylophilus, four cysteine proteases highly secreted by B. xylophilus (Cardoso et al., 2016) were selected four further characterisation. Materials and methods Results and discussion Structural prediction and analysis The i

• Unlike CRM exportins Cse and Xpot lack a C

  2020-03-07

  

  Unlike CRM1, exportins Cse1 and Xpot lack a C-extension and instead rely primarily on changes in HEAT-repeat conformation and direct Ran-cargo contacts to ensure low cargo-binding affinity in the cytosol and cooperative assembly of the exportin/Ran/cargo complex in the nucleus (Cook et al., 2005, Co

• br Results br Discussion Unraveling the molecular details

  2020-03-07

  

  Results Discussion Unraveling the molecular details of nucleoporin-karyopherin interactions, which have to be strong enough to promote transport but sufficiently weak to avoid stalling of transport complexes within the pore, is key to our understanding of the mechanisms of nucleocytoplasmic tr

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