• Finally our results suggest that R may at

  2020-03-09

  

  Finally, our results suggest that σ2R may, at least partially, mediate the hunger-suppressive action of amphetamine by interacting with orexigenic receptors in CRF2R-OX1R heteromer contexts. Despite extensive evidence supporting the formation of GPCR oligomers in heterologous systems, the lack of ap

• br Acknowledgments This research was supported by grants

  2020-03-09

  

  Acknowledgments This research was supported by grants from the Ministerio de Ciencia e Innovación (Grants SAF/FEDER 2010-17907; 2013-49076-P), Spain, Red de trastornos adictivos (RETICS RD12/0028//0003, Instituto de Salud Carlos III, Spain) and Fundación Séneca (15405/PI/10, Región de Murcia, Spa

• br Results br Discussion Cell

  2020-03-09

  

  Results Discussion Cell responds to fluctuating environmental factors by activating a set of compensatory mechanisms including changes in the lipid profile. Compensatory reactions occurring in membranes in response to phosphate deprivation include replacement of phospholipids by phosphorus-fre

• DNA methylation is a relatively stable

  2020-03-09

  

  DNA methylation is a relatively stable but reversible epigenetic mechanism that can regulate gene expression, and occurs at the three different cytosine sequence contexts (CG, CHG, and CHH, where H is C, A, or T) in plants [15]. Many studies suggest that DNA methylation status of genes influence pla

• The elastase induced injury model has been shown to

  2020-03-09

  

  The elastase-induced injury model has been shown to produce airspace enlargement, and increases in lung volume and compliance that are similar to those observed in human patients (Hantos et al., 2008, Hamakawa et al., 2011). Thus, this model, which has been used to study emphysema, should be adequat

• Canine ANGPTL7 / Angiopoietin-like 7 Protein (Fc Tag) br Ac

  2020-03-07

  

  Acknowledgements Introduction Water and electrolytes constitute an integral part of all living things, and Canine ANGPTL7 / Angiopoietin-like 7 Protein (Fc Tag) governing their movements play important roles in a wide variety of physiological and/or pathophysiological processes. Given the imp

• Resistance to avermectins has been

  2020-03-07

  

  Resistance to avermectins has been associated with point mutations of GluCls in C. elegans, D. melanogaster, T. urticae and P. xylostella (Dent et al., 2000; Dermauw et al., 2012; Kane et al., 2000; Kwon et al., 2010; Wang et al., 2016a, 2017). Our electrophysiological study found a 8.2-fold reducti

• br Introduction Cell transplantation therapies using

  2020-03-07

  

  Introduction Cell transplantation therapies using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC)-derived retinal tissue (ESC/iPSC retina) or thyrotropin releasing hormone have emerged as therapeutic options for retinal degeneration following recent breakthroughs. A number of g

• pyk2 In a study performed simultaneously by another group

  2020-03-07

  

  In a study performed simultaneously by another group, EWS-FLI-1 introduction into unsorted murine bone marrow-derived pyk2 resulted in tumors with various phenotypes including one that is consistent with that of Ewing sarcoma [68]. The tumors expressed markers associated with Ewing sarcoma and disp

• Introduction Psoriasis is a chronic recurrent and inflammato

  2020-03-07

  

  Introduction Psoriasis is a chronic, recurrent and inflammatory skin disease, and it is characterized by erythema, skin hyperplasia, scales, and hyperproliferation of keratinocyte [1]. It is reported that the psoriasis occurrences are about 3% worldwide [2], but the number varies depending on ethni

• As a support chitosan presents

  2020-03-07

  

  As a support, chitosan presents interesting characteristics that reinforce its great potential for enzyme immobilization [18,19]. Firstly, it is produced from renewable natural sources in addition to being biodegradable and water insoluble [20,21]. Also, the main peculiarity in the chitosan structur

• Our results from neutropenic mice infected with both

  2020-03-07

  

  Our results from neutropenic mice infected with both fungal strains revealed that the inflammatory process was more severe 72hours post-infection (Fig. 4). Angioinvasion was mainly observed 48hours after infection for both strains. Transformation of A. fumigatus conidia into hyphae in immunocompeten

• One of the most fundamental distinctions

  2020-03-07

  

  One of the most fundamental distinctions between Ub signals is substrate monoubiquitination versus polyubiquitination. With the exception of the E2, UBE2W, which represents a special case because it SID 26681509 only ubiquitinates the flexible N-termini of substrates [5], [6], [20], most examples o

• Moreover maintaining the pyrimidine pool is

  2020-03-07

  

  Moreover, maintaining the pyrimidine pool is not the only important role played by DHODHs. In Toxoplasma gondii, for instance, DHODH plays a second essential function [38] possibly coupled to the mitochondrial respiratory activity, where it replenishes ubiquinol levels and prevents reactive oxygen s

• br Results This study was

  2020-03-07

  

  Results This study was carried out with a series of engineered extracellular matrix films of collagen assembled at hydrophobic surfaces, which allow for independent control of supramolecular structure, mechanical stiffness, and receptor recognition sites [17], [21]. Vascular smooth muscle BS-181

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