• br Discussion Digoxin has multiple effects on

  2019-06-28

  

  Discussion Digoxin has multiple effects on the myocardium and has multiple cardiac-related uses. In the treatment of atrial fibrillation, digoxin increases vagal tone to prolong the refractory SJB2-043 of at the AV node, decreasing ventricular response to higher atrial rates [3]. Toxic doses of

• The aim of this study was to

  2019-06-27

  

  The aim of this study was to determine the therapeutic relevance of blocking RANKL in Ewing\'s sarcoma by using OPG administered by non-viral gene transfer approaches in two models of human Ewing sarcoma in immunodeficient mice. OPG was administered using amphiphilic polymers constituted by blocks o

• Many studies over the past years have

  2019-06-27

  

  Many studies over the past 20 years have shown the potential of urinary markers in the detection of the presence of bone metastases [3–11], the use of urinary markers for its prognostic value in bone disease [2,4,12–20], as well as directing therapy for bone metastases patients [2,6,12–18,21–25]. Th

• The gallstone Lith gene map has been

  2019-06-27

  

  The gallstone (Lith) gene map has been updated, which lists all known genetic loci that confer gallstone susceptibility, as well as candidate genes in inbred strains of mice. Understanding molecular genetics of gallstone disease in mice will push for the identification of human Lith genes. In additi

• Air pollution also has a substantial effect on the

  2019-06-27

  

  Air pollution also has a substantial effect on the wellbeing of people worldwide. This pollution can consist of sulfur dioxide, ozone, nitrogen dioxide, and fine-particulate Splitomicin of less than 2·5 μm in diameter (PM). 92% of the global population is exposed to higher-than-recommended concentr

• br Discussion Variant angina was

  2019-06-27

  

  Discussion Variant Tiopronin structure was described by Prinzmetal et al. in 1959 [1]. It can involve serious arrhythmias such as ventricular tachycardia, ventricular fibrillation, and atrioventricular block, and patients are particularly susceptible to sudden cardiac death in such cases [2,3].

• br Conclusions br Study limitations br Conflict of interest

  2019-06-27

  

  Conclusions Study limitations Conflict of interest Introduction Dabigatran etexilate, an orally administered pro-drug, is rapidly converted by a serum esterase to dabigatran, a potent, direct, and competitive inhibitor of thrombin. It has an absolute bioavailability of 6.5% and a serum T

• Preference for injectable therapy over oral therapy

  2019-06-27

  

  Preference for injectable therapy over oral therapy [17], contrary to our findings from a previous study [18], could reflect the fact that most patients have not received an oral bone-targeted agent for metastatic disease. However, the practical advantages of an injectable therapy and the lack of ne

• br Bone half life based dosing As zoledronic acid has

  2019-06-27

  

  Bone half-life based dosing As zoledronic rxr receptor has been shown to have anti-tumor efficacy in both the pre-clinical and clinical settings using the conventional regimen (zoledronic acid 4mg infusion 4 weekly), some studies were designed to explore the anti-tumor effects of zoledronic acid

• Introduction Atrial fibrillation AF is

  2019-06-27

  

  Introduction Atrial fibrillation (AF) is the most common cardiac arrhythmia managed in clinical practice and the most common arrhythmia requiring hospitalization [1,2]. Thromboembolism occurs with similar incidence, regardless of the form of AF [3,4]. AF management includes anticoagulation to preve

• Despite our best efforts the cause of

  2019-06-27

  

  Despite our best efforts, the cause of SCD in young individuals is sometimes not established; no cause is identified in up to 40% of cases. Importantly, whether a cause of death is established or not, the possibility of an underlying inherited cardiac disorder remains in many cases, including the po

• br As the only methods available for dual protection

  2019-06-27

  

  As the only methods available for dual protection against pregnancy and sexually transmitted infections (STIs), male and female condoms have a vital role in sexual and reproductive health. Mags Beksinska and colleagues therefore are to be commended for their randomised crossover trial in this Bra

• A su vez Paraguay expresa claramente

  2019-06-27

  

  A su vez, Paraguay expresa claramente en la Ley 3239, Artículo 3, inciso H que se tiende “[…] Aspartame la economía en el uso de los recursos hídricos. a través de su utilización racional y eficiente, posibilitando, así la disponibilidad para otros usos, previendo sobre su derroche, contaminación y

• Si se orienta seg n el procedimiento de

  2019-06-27

  

  Si se orienta según el procedimiento de la fórmula de transición adoptada, el mejor tipo de justicia transicional para Colombia sería el de las transiciones democráticamente legitimadas, el cual consiste en: Un modelo óptimo sería entonces el que combine tanto los perdones “responsabilizantes” y el

• De ser posible esta marcaci

  2019-06-27

  

  De ser posible esta marcación temporal, ¿no se correría el riesgo de fragmentar el pensamiento del autor? Por el contrario, si se contemplara todo el contenido de las obras de Morin con sus ideas de la complejidad, ¿no se asumiría el riesgo de globalizar y forzar su pensamiento? El propio Morin se

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