• Dig-11-ddUTP br On March the Indian Government banned around

  2019-06-11

  

  On March 10, 2016, the Indian Government banned around 330 “irrational” fixed-dose combination drugs (FDCs) with immediate effect. FDCs are products that Dig-11-ddUTP contain two or more active drugs in a fixed-dose ratio, and are useful for minimising pill burden and lowering cost. However, FDCs

• br Introduction Incidence of oral

  2019-06-11

  

  Introduction Incidence of oral cancers accounts for ∼3% of all malignancies. Oral squamous cell carcinoma (OSCC) accounts for >95% of all malignancies in the oral cavity, and it is the fifth leading cause of cancer death in the male population in Taiwan. OSCC is treated mainly with surgery. Post

• When the analysis was matching with

  2019-06-10

  

  When the analysis was matching with propensity score, OS was still significantly longer in JAK2+ patients (median not reached versus 73 months, p=.031) whereas JAK2 status had no significant prognostic value for OS in IPSS intermediate-2 and high patients (p=.18). Discussion In this series, whic

• In summary current evidence suggests that bone targeted

  2019-06-10

  

  In summary, current evidence suggests that bone-targeted agents reduce morbidity from metastatic disease to bone, and potentially improve quality of life in patients with metastatic breast cancer. As there are costs and potential adverse effects associated with these agents, care should be taken in

• The methods used for this

  2019-06-10

  

  The methods used for this purpose are, substantially, the analyses of atrial potentials, evoked atrial potentials [10], and ventricular rhythm in cases of stable spontaneous AV conduction [11]. Materials and methods Results Discussion This is the first report on the current ACAP Confirm® r

• br El fuego como fuerza destructora end gena Seg n

  2019-06-10

  

  El fuego como fuerza destructora endógena Según Elizabeth Monasterios Pérez, la poesía de Pacheco, al igual que la de Octavio Paz, por ejemplo, se nutre de cosmología prehispánica. Con todo, prosigue Monasterios Pérez, Pacheco se demarca de Paz mediante la configuración de un “principio apocalípt

• Modelling studies have estimated that

  2019-06-10

  

  Modelling studies have estimated that the implementation of Xpert MTB/RIF, either in addition to or as a replacement to smear microscopy, will be cost-effective for the diagnosis of tuberculosis and mutidrug-resistant (MDR) tuberculosis in countries with a high burden. The incremental cost of each d

• br Discussion ATRA and arsenic

  2019-06-10

  

  Discussion ATRA and arsenic are both known to induce differentiation syndrome but this case was notable for its severity. Previous studies of differentiation syndrome have demonstrated that APL order Afatinib treated with ATRA secrete the chemokines CCL2 and IL-8, which in combination with chemo

• br A modo de conclusi

  2019-06-10

  

  A modo de conclusión La re/visión que se ha propuesto en el presente escrito recoge el sentido que le da Adrienne Rich al término: revisar es volver a mirar desde un posicionamiento crítico en un presente, desde el que se tiene una perspectiva (temporal) de cómo ha sido la suerte del fenómeno que

• EBV occasionally reactivates to switch its replication mode

  2019-06-10

  

  EBV occasionally reactivates to switch its replication mode from latent to lytic, producing a large number of infectious virions with the lysis of host cells [7]. Although reactivation is dangerous for the virus, its triggering factors have not yet been identified. EBV reactivation is associated not

• br Introduction The early repolarization ER pattern

  2019-06-06

  

  Introduction The early repolarization (ER) pattern has been considered a benign electrocardiographic phenomenon affecting 2–5% of the general population and is most commonly seen in healthy young men and athletes [1–3]. Recent studies have challenged the view of this electrocardiogram (ECG) varia

• According to Weitzman classification patients had a single

  2019-06-06

  

  According to Weitzman classification [43] 15 patients had a single ONJ lesion (4A) and 9 patients had multiple lesions (4B) or a “multifocal” lesion (Table 2). Six patients interrupted the treatment with O3 gas application for disease progression (five patients) and for fear of an experimental ther

• In the normal BMD subgroup there was progressive

  2019-06-06

  

  In the normal BMD subgroup, there was progressive bone loss over 3 years at the spine and hip (5.4% and 4.5%, respectively). This finding is consistent with the ATAC data [5]. Two patients required alendronate triggered by clinical events but there were no algorithm triggered events. There were no n

• We are aware that physician surveys

  2019-06-06

  

  We are aware that physician surveys have been previously used to assess; bisphosphonate use for bone pain [14], bisphosphonate use in metastatic breast cancer patients [15] and radiotherapy use for painful bone metastases [16] but are not aware of physician surveys being used to help design trials o

• Cell adhesion to extracellular matrix requires the interacti

  2019-06-06

  

  Cell adhesion to extracellular matrix requires the interaction of different molecules like selectins, cadherins and integrins [21]. Especially αvβ3 integrin has been proposed to mediate the adhesion of malignant cells in different entities such as multiple myeloma and breast cancer [22,23]. Upon exp

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