• Acute kidney injury is a common

  2019-05-09

  

  Acute kidney injury is a common disorder worldwide, occurring in more than 13 million people every year, 85% of whom live in low-income or middle-income countries (LMICs). The disease imposes a severe burden of morbidity and mortality, with a major economic effect on health-care expenditure worldwid

• Stimulated IUI is much more effective than

  2019-05-09

  

  Stimulated IUI is much more effective than natural Oxamflatin or controlled ovarian hyperstimulation treatment. In four randomized trials of patients with unexplained subfertility, pregnancy rates were higher when IUI was performed in stimulated cycles than in natural cycles [odds ratio (OR): 2.14;

• br Discussion The implant of a CRT device in a

  2019-05-09

  

  Discussion The implant of a CRT device in a patient with a resting ejection fraction of 50% represents off-guideline use of this therapy [1]. However, since the patient׳s significant NYHA Class III symptoms, LBBB and exertional ventricular dysfunction achieved evidence-based levels for improvemen

• br How do you manage patients

  2019-05-09

  

  How do you manage patients on intravenous bone-targeted agents who require dental work? For patients who are on IV bisphosphonate therapy and require dento-alveolar procedures there is a suggestion that prophylactic antibiotic use around the procedure may be helpful in reducing ONJ risk [45,49].

• regulator of g protein signaling In Alexandre de Figueiredo

  2019-05-08

  

  In , Alexandre de Figueiredo and colleagues take a step in this direction with their time-series analysis of trends in vaccine coverage and a suite of socioeconomic and demographic factors across 190 countries over 30 years. The main aim was to gauge where and when regulator of g protein signaling c

• Cisplatin based chemotherapy is commonly used in

  2019-05-08

  

  Cisplatin-based chemotherapy is commonly used in adjuvant CCRT, but data on carboplatin-based chemotherapy with radiotherapy is lacking. Khoury et al reported that patients treated with carboplatin-based chemoradiotherapy show worse outcomes. However, the impact on patient comorbidities was not repo

• In addition to inducing IKs dysfunction

  2019-05-08

  

  In addition to inducing IKs dysfunction through dominant-negative loss-of-function effects and defective channel trafficking, mutations in KCNQ1 suppress IKs channel function by reducing the channel affinity of interacting proteins [68,69]. Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor

• br Epigenetic regulation of genes involved in hepatic lipid

  2019-05-08

  

  Epigenetic regulation of genes involved in hepatic lipid metabolism by S1P and SHP The signaling cascade of CBA > S1PR2 > SphK2 > S1P > HDAC1/2 > increased hepatic gene expression can differentially up-regulate blocks of genes involved in the hepatic metabolism of sterols and lipids (Fig. 3, Tabl

• Buturovic and Ignatovic rightly point out

  2019-05-08

  

  Buturovic and Ignatovic rightly point out that present-day formula is different from the type of milk received by Brazilian infants born in the early 1980s, particularly because long-chain polyunsaturated fatty acids have been added to modern products. Nevertheless, modern biology is constantly unco

• In addition to being a key determinant of the

  2019-05-08

  

  In addition to being a key determinant of the risk of acquiring infection, nutritional status is a principal determinant of the health trajectory and outcomes following discharge from hospital. Among Gambian children admitted with pneumonia, even being moderately underweight was associated with a ra

• Al observar las cuatro constituciones

  2019-05-08

  

  Al observar las cuatro constituciones (Brasil, Argentina, Paraguay y Uruguay) se destaca una ejemplar redacción del Artículo 47 de la Constitución de Uruguay, al definir cuál es la prioridad en el uso del recurso además de determinar no sólo la participación social en la planificación de estrategias

• Importance of heart failure Acute decompensated heart failur

  2019-05-08

  

  Importance of purchase AMG-900 failure Acute decompensated heart failure (ADHF) refers to a clinical condition of worsening HF with dyspnea, often with evidence of fluid overload [1]. This is generally triggered by 1 of the 4 main factors: atrial fibrillation, anemia, hypertension, and medication/d

• Bisphosphonates are the cornerstone of management in postmen

  2019-05-08

  

  Bisphosphonates are the cornerstone of management in postmenopausal osteoporosis with randomised trial evidence of reductions in vertebral fractures for ibandronate [15] and both vertebral and non-vertebral fracture rates for alendronate [16], risedronate [17], and zoledronic hiv fusion inhibitors

• br Conclusions br Limitation br Acknowledgments

  2019-05-08

  

  Conclusions Limitation Acknowledgments This research was supported in part by the China Postdoctoral Science Foundation (Nos. 2013M542478 and 2015T81139), a Grant (no. 2014FB059) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical Uni

• Patients with DLE had a fold

  2019-05-07

  

  Patients with DLE had a 4.6-fold higher rate of local recurrence than those without DLE. The 5-year local control rates were 20% and 91% in patients with and without DLE, respectively. DLE creates serious problems not only in inserting the endotracheal tube but also in performing MLS in patients und

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